Osteogenesis Imperfecta is a genetic disorder resulting in brittle bones. Osteogenesis Imperfecta (OI) or brittle bone disease, is a serious bone disorder that affects children from birth. It is often so severe that children are born with broken bones and continue break bones their whole life. Even children with mild OI tend to break one bone every year and children with more severe OI can have numerous breaks in one year. The bones of the arms and legs often become bowed and the spine bones can be affected with ‘crush fractures” and curvature of the spine. It’s not just the bones that are affected, but also the teeth are brittle and the muscles are weak. OI occurs when the basic building block of bone, a mesh-like material called collagen, is not made properly. Because it occurs due to an abnormality of the gene that makes the bone collagen, there is no cure. Treatment to improve the life of children and adults with OI has come a long way in the last decade, but there is much more to learn.